The Cruz-Acuna Lab focuses on integrating aspects of biomaterial engineering, cell and molecular biology, and 3D organoid biology to (1) understand the contributions of the extracellular matrix properties to metaplasia and tumorigenesis, and (2) identify mechanisms important for esophageal developmental patterning and organogenesis. We are currently recruiting a post-doctoral research scientist interested in understanding the cell-extracellular matrix interactions that drive esophageal intestinal metaplasia and its progression to cancer. Studies will include classic molecular and cell biology techniques, novel engineered hydrogels, patient-derived and hiPSC-derived 3D organoid in vitro platforms, and in vivo xenograft models. Successful completion of this proposal will be both scientifically and clinically significant by defining the contribution of matrix properties to mechanisms of metaplasia and laying a foundation for novel therapies to disrupt matrix properties in tumorigenesis.

The Cruz-Acuna Lab is committed to building a diverse and inclusive work environment that achieves the goals of creating a scientific workforce that reflects all perspectives and experiences.

Columbia University is a leader in biomedical research and is a National Cancer Institute-designated Comprehensive Cancer Center. The Herbert Irving Comprehensive Cancer Center (HICCC) at Columbia University Irving Medical Center provides outstanding Biomedical Research Cores. The HICCC houses 12 core facilities or shared resources that provide services essential to basic and translational cancer research, to which the applicant will have continued full access on a 24/7 basis.

Minimum Degree Required

• Ph.D., MD, or equivalent doctoral degree

Minimum Qualifications

• Applicants must have a Ph.D., M.D., or equivalent degree
• Excellent experimental and analytic skills and willingness to learn the new model system and methodologies.
• Self-motivated with a strong interest in studying the mechanistic and translational aspects of gastrointestinal diseases.
• Effective communication and writing skills and record of publication in a peer-reviewed journal(s)
• Ability to work independently and collaboratively.
• Experience in cell culture and molecular biology techniques.

Preferred Qualifications

• Experience in biomaterial (hydrogel) synthesis and characterization (recommended, not required).

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.